Studies in vitro indicate that asenapine has a weak inhibitory action on isoenzyme . Clinical studies of drug interactions that have examined the effects of inhibition of trenbolone acetate stack with isoenzyme asenapine, showed the following results:
– Measures the ratio of dextrorphan / dextromethorphan as a marker of isoenzyme activity after co-administration of dextromethorphan and asenapine in healthy volunteers. The use of asenapine in a dose of 5 mg twice daily resulted in a reduction of the ratio to 0.43, indicating that inhibition of isozyme . In the same study, the treatment with paroxetine 20 mg / day, the ratio decreased to 0,032.
– In a separate study, a simultaneous single dose of 75 mg of imipramine and 5 mg of asenapine did not affect the concentration of the metabolite desipramine .
– Simultaneous single dose 20 mg of paroxetine during use of asenapine in a dose of 5 mg twice daily in healthy male volunteers resulted in almost two-fold increase in AUC of paroxetine.
In vivo asenapine may have only a weak inhibitory action on isoenzyme trenbolone acetate stack with. However, asenapine may enhance the inhibitory effects of paroxetine on its own metabolism.
Therefore, the drug should be used with caution in combination with drugs that are substrates or inhibitors of isoenzyme .
Effects on ability to drive and use sophisticated technology
preparation Influence trenbolone acetate stack with on the ability to drive and use sophisticated techniques have not been studied. Asenapine may cause somnolence and sedation. Therefore patients should not drive a car and machinery until they are certain that the drug does not render them undesirable effect. mixbol?