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trenbolone acetate powder

The content of the drug in the blood of human patients reaching a peak after 2 hours after taking 60 mg (1 tablet); over night in serum has determined its small quantity. In the selection of blood after 9 hours after the 30-day course of treatment at different patients detected from 0 to 89 ng / ml trenbolone acetate powder .
The study pharmacokinetics  was also performed on mongrel intact rats and animals with sarcoma 45. The drug is rapidly absorbed from the gastrointestinal gastrointestinal tract; purification from blood it ends at the 25-28 th hour after intragastric administration of 100 mg / kg.
The maximum blood concentration of intact animals after about 50 minutes after administration in tumor (sarcoma 45) -. 3 through chasa
Registered increased in 3-5 substance accumulation in the liver, kidney and lung in comparison with blood, but not in the tumor; purification of intact organs of healthy animals with tumors and ends at the end of 4 days. Urinary excretion in healthy animals continues to 3 days and is approximately 50% of the injected quantity; at tumor removal ends between the first and second days, and displays only 25% of the drug. Volume of distribution, in intact rats is 14 ml, the presence of tumor – 29.4 ml. Tumor prone to accumulation trenbolone acetate powder .
The body is oxidized, and his undefeated portion excreted in the urine, partly acetylated form (rats and rabbits).

Indications
Symptomatic treatment of locally advanced and disseminated forms of cancer. This has a pronounced symptomatic effect: the reduction or elimination of pain (up to the failure of the drug), feelings of weakness, the phenomena of respiratory failure (shortness of breath), cough, fever, improve appetite, increased physical activity. The drug is prescribed to patients with malignant tumors in advanced stages (including preterminalioy phase of the process).

Contraindications

 

  • Hypersensitivity to the hydrazine sulfate and other components of the formulation.
  • Concomitant use with all kinds of alcohol and barbiturates.
  • Pregnancy and lactation.
  • Children’s age (due to the lack of application experience).Precautions: when expressed violations of liver and kidney function.Side effects
    are possible dyspepsia (nausea, vomiting, belching), quickly passing at lower doses or short-term (two-, three-day) break in treatment.
    Rare complications -. Insomnia, general arousal, are not pronounced and transient phenomena of polyneuritis
    prescribed for dyspepsia inside astringent and anti-inflammatory drugs (camomile tea, romazulan, vikalin), antispasmodic and anti-emetic drugs. By appropriate use of the neurotoxic effects of pyridoxine hydrochloride (5% solution of vitamin B6 and 1 ml intramuscular injection 1-2 times per day), thiamine chloride (vitamin B1), multivitamin preparations and intravenous inwardly 20-40% dextrose (glucose).

    Interaction with other drugs and other forms of interaction
    Simultaneous reception  with barbiturates, ethanol, tranquilizers, antipsychotic drugs (neuroleptics) can lead to a sharp increase in toxicity.
    In experiments on laboratory animals in the case of pre-admission  effective treatment of many anticancer drugs increases (with the exception – cyclophosphamide).

    Cautions
    Treatment should be under the supervision of a physician who is experienced in the use of anticancer drugs.
    The drug is prescribed with caution to patients with the expressed violations of liver and kidney function. Use of the drug in jaundice caused by liver metastases (especially obstructive) is not contraindicated.
    It is necessary to exclude the use of ethanol-containing beverages as well as foods rich in tyramine:. Cheese, raisins, canned foods, sausages, yoghurt
    In the absence of myelotoxicity trenbolone acetate powder is used in patients with cytopenia resulting from radiation therapy and chemotherapy.

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