In the short-term (6 weeks) clinical studies have demonstrated that the dependence on the dose rate of akathisia in patients with schizophrenia treated with asenapine. A tendency trenbolone acetate 100mg to increase with increasing frequency parkinsonism doses.
in older patients in the combined study phases 2 and 3, the incidence of orthostatic hypotension was 4.1% compared to 0.3% with respect to all the patients who participated in these studies.
The increase in body weight
in the short-term and long-term clinical trials in patients with schizophrenia and bipolar mania the body weight in the treatment with asenapine increased by an average of 0.8 kg.
The proportion of patients with clinically significant weight gain (? 7% of the original mass) in short-term studies in patients with schizophrenia was 5.3% in patients treated with asenapine, compared with 2.3% in the placebo group. The proportion of patients with clinically significant weight gain (? 7% of the original mass) in short-term studies in patients with bipolar mania was 6.5% in patients treated with asenapine, compared with 0.6% in the placebo group.
Other side effects
Asenapine has anesthetic properties. Paresthesia and hypoesthesia of the oral cavity can occur immediately after drug administration and usually disappear within 1 hour.
are available postmarketing reports of serious hypersensitivity reactions in patients treated with asenapine, including anaphylactic / anaphylactoid trenbolone acetate 100mg reactions such as edema tongue and pharyngeal edema.
There are reports of oral mucosal lesions in patients treated with asenapine, including ulcerations, blistering and inflammation. Local anesthetic properties of asenapine should be considered as a possible alternative causative factor of the symptoms from the oropharynx.
Changes in liver enzyme activity in the blood
Transient asymptomatic increase of liver transaminases, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were observed frequently, especially at the beginning of therapy.
In clinical studies, asenapine was observed a few cases of overdose. Calculated doses ranged from 15 mg to 400 mg. In most cases, it was unclear whether the patients took asenapine sublingual. Adverse events associated with taking the drug included agitation and confusion, akathisia, orofacial dystonia, sedation, and asymptomatic ECG changes (bradycardia, supraventricular arrhythmias, slowing intraventricular conduction).
Specific information about the treatment of overdose with asenapine not. Antidote to asenapine did not exist. It is necessary to consider the possibility of an overdose as a result of receiving multiple drugs. It is necessary to monitor the function of the cardiovascular system to diagnose potential arrhythmias. In case of overdose showing supportive care, adequate oxygenation and ventilation of the respiratory tract and symptomatic treatment. By reducing blood pressure and collapse, according to Ministry of Health guidelines, require adequate measures, including intravenous fluids and / or sympathomimetic agents (epinephrine and should not be administered dopamine, as the stimulation of β-adrenergic receptors may contribute to a further decrease in blood pressure during the blockade of α-adrenergic receptors under the influence ). In the presence of severe extrapyramidal symptoms prescribed m-anticholinergic agents. The patient should be monitored carefully while his condition is not normal.
Interaction with other drugs
The influence of other drugs on the pharmacokinetics of the drug trenbolone acetate 100mg
Asenapine is derived mainly through direct glyukuronirovaniya under the influence of isoenzyme and oxidative metabolism by the action of cytochrome isoenzymes . It has been studied the possible effect of inhibitors and inducers of several of these isoenzymes on the pharmacokinetics of asenapine, namely, fluvoxamine , paroxetine , imipramine , cimetidine , carbamazepine and valproate.Except for fluvoxamine, clinically relevant changes in the pharmacokinetics of asenapine were not revealed while the use of the above drugs. The simultaneous use of fluvoxamine 25 mg twice a day with asenapine 5 mg once a day resulted in an increase of asenapine values by 29%. It can be expected that the full therapeutic dose of fluvoxamine, will induce a more pronounced increase of asenapine plasma concentrations. In the application of asenapine in combination with fluvoxamine should be careful.
Possible effects of the drug trenbolone acetate 100mg on the pharmacokinetics of other drugs
Due to the fact that asenapine has α 1 adrenoblokiruyuschee properties and can cause orthostatic hypotension (see. “Precautions” section), the may enhance the effects of certain antihypertensive agents.